Take a look.
|Advanced Time Schedule - auto replies for Postfix and Sendmail|
The new feature is Daily pattern option which give you a possibility to set active rules only at particular days in week.
If you want to sent auto replies all week then option No pattern must be selected but when you're out of office at weekends then Daily pattern comes for the help with Sunday and Saturday option.
Check this new feature and your autoresponses will be like never before.
With those features which MSH Autoresponder have you can throw away vacation and forward scripts to bin and never look back.